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Additionally, lactate treatment has been observed to enhance the expression of hypoxia-inducible factor (HIF)-1, PD-L1, and H3K18 acetylation in PCa cells, which in turn promote tumor angiogenesis (144)

todos estos procesos se alteran en tumores y por lo tanto los inhibidores HDAC tienen alta actividad antitumoral28

We observed that mRNA expressions of Th1 cytokines such as IL-2, IFN- and TNF- as well as cell proliferation rate were inhibited by Gpx inhibitor in Jurkat T cells