glutathione peroxidase and cardiovascular disease Emerging roles of ferroptosis in diseases Glutathione deficiency and heart failure:

For these individuals, introducing supplemental sulfur donors like glutathione or N-Acetyl-l-Cysteine (NAC) can sometimes trigger paradoxical mast cell reactions, causing symptom flares, hives, or worsened tachycardia

These in vitro findings corroborate the patient tumor tissue data (Fig

In addition, glutathione plays a role in immune regulation and detoxification pathways

PMID: 36176909 Adv Sci (Weinh) Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib-Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency

Under hypoxic conditions, mitochondria produce more ROS

The FSP1/CoQ10 pathway suppresses lipid peroxidation and ferroptosis by utilizing FSP1 to regenerate reduced CoQ10, a lipophilic radical-trapping agent, via NADPH