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The present review summarizes ferroptosis-related mechanisms across AD, PD and DACI, emphasizing both the common molecular features and the unique triggers in each disease

Iron overload downregulates GPX4 and SLC7A11 expression in chondrocytes and activates the p53/ACSL4 axis, driving lipid ROS accumulation and ferroptosis

334 Beyond degradation failure, autophagy-lysosomal dysfunction contributes to the pathological propagation of aggregation-prone proteins

Likewise, results obtained in various diet-induced MASLD/MASH rodent models revealed a marked reduction in CAT activity in the serum as well as the liver of these animals as compared to respective controls (Dai et al

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626,627,628 Experimental evidence is accumulating that astrocytes readily respond to lifestyle modifications, and may be instrumental in conferring clinical benefits