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Tranexamic Acid (TXA) interrupts melanin production at the source effective on stubborn spots, melasma, and sun damage

doi: 10.1007/s00424-020-02441-x 122 KolA.AdamskyA.GroysmanM.KreiselT.LondonM.GoshenI

(3) Confirming that the IVs solely influence the risk of the outcome through their association with the exposure, without exerting a direct impact on the outcome itself

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Mitochondrial respiratory chain complexes I (NADH-CoQ reductase complex), II (succinate dehydrogenase complex), III (cytochrome bc-1 complex) can, under different metabolic stress, produce ROS that damage the mitochondrial membrane, resulting in lipid peroxidation and ultimately leading to ferroptosis