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Eur J Neurol 17:14631470

Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain region

doi: 10.1038/cdd.2014.218 275 KolahgarGSuijkerbuijkSJKucinskiIPoirierEZMansourSSimonsBDet al

The study shows that female patients with melanoma had significantly better responses to BRAFMEK-targeted therapy than male patients, and in preclinical melanoma models, elevated AR expression impaired treatment efficacy, while AR inhibition improved responses

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