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2.7 Metabolite analysis Online metabolite databases (KEGG, HMDB, PathBank) and the literature were used to link the statistically significant metabolites to metabolic pathways

High concentrations of resveratrol may inhibit mitochondrial complex I, while synthetic activators like SRT2104 require high doses due to poor liver targeting, increasing oxidative stress risk in extrahepatic tissues

While nausea, vomiting, and diarrhea commonly occur with tirzepatideparticularly during dose escalationsevere symptoms may require dose adjustment, temporary treatment interruption, or additional supportive care