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The principal proteolytic enzymes, MMPs and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are upregulated (Le Maitre et al., 2007)

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doi: 10.1016/S03037207(00)002525 275 JohnsonJDChangJP

Studies have shown that whole body retention of vitamin B12 at 14 days in elderly subjects is comparable to that in younger individuals, indicating that age does not significantly affect vitamin B12 absorption