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10.1016/j.biopha.2017.04.095 213 ZhangS.KangL.DaiX.ChenJ.ChenZ.WangM.et al (2022a)

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Of importance, additional work is required to elucidate the mechanisms of lipid peroxides triggering necroptosis and upstream kinases involved in this process

But when we looked at the data of User 22, we found a legitimate contradiction

Disruption of NADPH production compromises GSH regeneration, limits GPX4-dependent detoxification of lipid peroxides, and can promote ferroptosis even in the absence of impaired GSH synthesis 152