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From the genetics angle, there are some pediatric, congenital causes of 5-oxoprolinuria which not surprisingly involved defects in enzymes of the gamma-glutamyl cycle (in particular, mutations in glutathione synthetase and 5-oxoprolinase have been identified in these patients).

Gadolinium has also been detected in drinking water in Berlin, London, and Prague [55]

Model of autism: increased ratio of excitation/inhibition in key neural systems

Indeed, in 2010, an expert panel of the American Academy of Pediatrics strongly recommended further investigation into the role of GI abnormalities in the pathophysiology of ASD [74]

66% and 34% of patients had Child Pugh A and B cirrhosis, respectively

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