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It is worth mentioning that a recent study found that in tumors, the metabolite lactate affected the TME by regulating the lactylation of MOESIN in Tregs and enhancing TGF- signal transduction, thus promoting a new mechanism of tumorigenesis 266

In ovarian cancer, three heterogeneous clusters (cluster 0, 3, and 4) emerged within HGSOC-1 and two clusters (cluster 1 and 2) in HGSOC-2 (Fig

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There is limited clinical data published on intrathecal iron chelation in neurodegeneration, and no iron chelator is officially approved for IT use, given that this is a rather invasive experimental approach

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