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Research using HCC cell lines and animal models has found that methionine restriction or inhibition of MAT2A with FIDAS-5 induces cellular senescence in HCC and that combining these pro-senescence therapies with senolytic agents, such as GSK3 inhibitors that clear senescent cells, synergistically enhances antitumor efficacy [95,171]

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doi: 10.3390/ijms20081930

Autophagy and oxidative stress associated with gold nanoparticles