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however, this review is different in that it includes a broader range of the available medical treatment options and only includes randomised control trials, a meta-analysis was not conducted due to the heterogeneity of the data

Conceiving of the study, participated in its design, study supervision, obtained funding and helping to draft the manuscript

Therefore, the CS regulation, at both enzymatic and epigenetic levels, plays a pivotal role in tumors, suggesting new druggable pathways for prevention and treatment of human cancer