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Dihydrocodeine concentrations at the effect site were obtained by convolution of a first-order transfer function with the function describing the plasma concentration versus time courses, and miotic effects were related to effect-site concentrations by a sigmoidal pharmacodynamic model

4 Mechanistic pathways linking oxidative stress to male infertility 4.1 Lipid peroxidation of sperm membranes and consequences for motility and fusion Spermatozoa are uniquely vulnerable to lipid peroxidation owing to their plasma membranes being enriched with polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA) (77)

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