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Active lesions in relapsingremitting MS (RRMS) and progressive course patients were associated with inflammation, lipid peroxidation, and DNA oxidation [11]

1997 September 81 (3):311-9

Consistent with its disruptions of mitochondrial respiration reflected in the cells OCR measurements, CB-839, starting at low concentrations of 0.1 to 1 M, also decreased the ATP pool in the HG-3 (P = 0.02) and MEC-1 (P = 0.01) cell lines, as measured using high-performance liquid chromatography ( Figure 2D ).The levels of other nucleotides remained stable at all concentration points

This is consistent with the findings reported in PK studies [44, 45]

Lyophilised powder, sealed and batch-traceable