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This characteristic means deficiency develops slowly, often taking years to manifest

Biogerontology 16(6):693707 Chai Z, Gatti S, Toniatti C, Poli V, Bartfai T (1996) Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1: a study on IL-6-deficient mice

On the other hand, ROS inhibit the differentiation and function of osteoblasts and further disrupt bone formation by inducing osteoblast apoptosis (100)

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