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A major limitation in this field currently is a lack of animal and human experimental studies that validate in vitro and in vivo cell line and PDX work

Statistical methods Variables were reported as percentages or means SD as appropriate

Wild-type IDH1 overexpression fully rescued the phenotype, demonstrating that the observations are not due to off-target effects (Extended Data Fig

75 The most practical method of ensuring sufficient substrate is a 300 g marine fish meal followed by a random urine collection 212 hours after the meal or alternatively in the Nijmegen protocol, timed urine collection for 68 hours post meal

6A), and the results indicated that the level of green staining was increased in RTCs treated with PFOS, indicating increased PFOS-induced LMP

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