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The treatment also reduced the key tight junction protein, occludin, at the cell membrane, and increased acidic mucins and extracellular alkaline phosphatase activity

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Despite the inherent challenges of predicting clinical phenotypes in diploid humans, our patient CBS activity scores, derived from variants that had been individually assessed in a haploid yeast model, correlated significantly with age of disease onset and with disease severity

Authorship X.F.H., A.L., and H.M.C

Increased necrosis was observed amongst the untreated granulomas (Figure 2M)

Angewandte Chemie International Edition in English , 27 (1), 539