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Data were collected from parents through a self-administered questionnaire and from study subjects through a face-to-face interview by trained data collectors

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The protocol first involved collating various kinetic values from literature, and assigning each value a weight to represent their plausibility, based on the organism, enzyme and conditions under which the kinetic parameter was measured

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Ethics approval and consent to participate The "Guide for the Care and Use of Laboratory Animals" and the Ethical Committees approval of the Faculty of Science, Suez University, Suez, Egypt, for the use of animal subjects guidelines were followed in all experimental procedures

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