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Some research data suggests it may also interact with alternate pathwaysfor example, via -adrenergic receptorsto support breakdown of fat cells further while potentially avoiding the mitogenic and glycemic risks associated with intact hGH

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In subjects with renal impairment including end-stage renal disease (ESRD), no change in tirzepatide pharmacokinetics (PK) was observed [see Clinical Pharmacology (12.3)]

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