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There are many other metabolic pathways that could be targeted to limit the inflammatory and dysmetabolic consequences induced by TBI (245)

In the investigation of iron overload-induced bone marrow cell death, the levels of ROS and the initiation of apoptosis are primarily linked to the mitogen-activated protein kinase (MAPK) pathway [98]

This therapeutic agent was approved by the US Food and Drug Administration (FDA) in 2007 for the treatment of advanced renal cell carcinoma

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Optimal use: deep intramuscular injection only, daily dosing in the correction phase then weekly maintenance, with B12 blood test before and after to assess response

Bernauer et al