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Its endogenous form has a plasma half-life of only 2-3 minutes due to rapid degradation by dipeptidyl peptidase-4 (DPP-4) and renal clearance

Using a moisturizer and starting slowly can help reduce peeling

CVD is a general term that describes a disease of the heart or blood vessels, such as coronary heart disease

It is found naturally in animal-based foods and has a complex absorption pathway involving intrinsic factor and the terminal ileum

11 The anatomical linchpin is the area postrema, a small hindbrain structure that sits outside the bloodbrain barrier and is therefore directly exposed to circulating hormones

According to NICE Clinical Knowledge Summaries and the British National Formulary , the standard treatment is intramuscular injections of 1,000 mcg (1 mg) hydroxocobalamin