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To view or add a comment, sign in My new article on the early warning signs of MSK issues and how to address them is up on the British Chiropractic Association's 'Knowledge Hub'

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The diagnostic process typically involves: Clinical history taking, focusing on symptoms (fatigue, neurological changes, dietary habits) Physical examination for signs of anaemia or neurological impairment Blood tests including full blood count, serum B12, and often folate levels Additional investigations such as intrinsic factor antibodies or parietal cell antibodies if pernicious anaemia is suspected For borderline results, additional tests like holotranscobalamin (active B12) may be considered NICE guidance recommends that treatment should commence based on clinical presentation if neurological symptoms are present, without waiting for laboratory confirmation, as delays can result in irreversible nerve damage

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This cytokine modulation appears to be a key mechanism underlying its efficacy in models of inflammatory bowel disease, surgical wound healing, and systemic inflammatory injury

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