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Ivashkin VT, Maevskaya MV, Zharkova MS, Zhigalova SB, Kitsenko EA, Manukyan GV, et al

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Under such metabolic stress conditions, supplies of L-cysteine for glutathione synthesis become limiting, so homocysteine is diverted from the transmethylation pathway forming methionine into the transsulfuration pathway forming cystathionine

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The proposed mechanisms are multiple and interconnected, reflecting the broad biological footprint of copper-dependent biology in mammalian tissues