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(2011) analyzed differences in the expression levels of MPO-related genes between a stroke group and a control group and found a positive correlation between the rs8178406 sequence in the MPO gene and stroke occurrence, providing the additional evidence that MPO is involved in stroke susceptibility and demonstrating a significant correlation between the MPO gene and stroke occurrence

The neuroprotective effects of the ketogenic diet further extend to synaptic plasticity regulation: by increasing -hydroxybutyrate (BHB) levels, it directly activates the ERK/CREB signaling pathway in the hippocampus, promoting brain-derived neurotrophic factor (BDNF) synthesis (especially in females) to restore impaired long-term potentiation (LTP) in Alzheimers model mice

Propidium iodide (PI, CAS 25535-16-4

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This dual dysfunction of microglia and astrocytes leads to extensive oxidative stress, immune activation, and eventual neuronal degradation

Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils